The study was conducted in 2009-2012 in the experimental field of IPGR “K. Malkov”-Sadovo. The aim of the investigation was to establish the productive capacity of twenty winter wheat genotypes (4 varieties and 16 lines) and their resistance to the Fusarium head blight- Fusarium culmorum was established. The accessions were studied by using a block design with 4 replications and plot size of 10 m2. The relatively highest yields were obtained from lines 73-31-5 and 660 surpassing Sadovo 1, by 9.04% and 8.91% respectively. The significantly higher yields were obtained from the Farmer, Panacea and Pobeda varieties. Lines 135-56-1, 265-12, 27-43-11a, 471-1, 471-2, 491-12, 470-9 and 521-4 showed the lowest productivity. Two-way ANOVA was applied to determine whether the variability of the trait depends more on genetic factors or on the growing conditions. In our study the environment showed the greatest effect on the variability of the trait (72.29%). Resistant varieties and lines to the agent of the Fusarium head blight (Fusarium culmorum) in the studied wheat genotypes were not reported. Seventeen samples belonged to the sensitive samples group with infected seeds attacks from 25.01% to 50%. Three of the studied samples (470-9, 372-5 and 347-3) were in the group of the highly sensitive to the agent of Fusarium head blight (Fusarium culmorum) with 50% infected seeds.