The preliminary results of studies of immunogenic structure of the population Holstein cows Dutch selection, introduced and bred in SRL «Docsankom» vlg Tomai, Chadyr-Lunga region of the Republic of Moldova. The studies were performed in order to control breeding and genetic processes in a population during a period of acclimatization of animals in the new environment and deepen ideas about the specifics of their breeding value. Analysis of the genetic structure of the population (n = 202) was conducted by erythrocyte antigens of 9 genetic systems (A, B, C, F-V, J, L, M, S, Z). The presence of 45 of the 49 studied antigens was detected. The frequency of their distribution varied from 0.0049 (antigen Z’ EAA locus) to 0.9356 (antigen F EAF-V-locus). Widespread antigens G2, E’2, O’, Q’, G” (frequency 0.2030 – 0.5297), antigens C2, E, W, X2 (frequency 0.4010 – 0.5891) and antigen F (frequency 0.9356). The results obtained are of practical importance for the recovery genetic resources of dairy cattle of the Republic of Moldova by pure breeding as well as to increase productivity and breeding qualities of local breeding animals by crossbreeding.